BIOCHEMICAL FARMACO RESEARCH INSTITUTE
The Institute of Biochemical Drugs Research (IIFB), belongs to the Faculty of Pharmaceutical and Biochemical Sciences, of the Universidad Mayor de San Andrés, located at Avenida Saavedra No 2224, Miraflores.
The IIFB was created with the purpose of having a structure that allows the development of scientific and technological research from a multi-interdisciplinary approach to natural products and biotechnology applied to plants and microorganisms, which are part of various ecosystems, and contribute to the training of human resources of high academic level for the research and execution of projects associated with sustainable development (biological control of pests), the environment (bioremediation and biodegradation) and traditional medicine (traditional pharmacopoeias), through programs of :
Formative Research: It is carried out with the chairs in coordination and advice of the IIFB. The main objective is the training of human resources in the field of research.
Generative Research: Generate knowledge and answers to the problems of the country and region in which to make health, biotechnology and the environment.
MICROBIAL BIOTECHNOLOGY AREA
We work in the isolation, partial characterization, maintenance and fermentation of microorganisms obtained from samples of various ecosystems, in order to support the agricultural, environmental, mining, industrial, among others, through the development of pest control (microbial ) in crops of economic interest (potato, bean, chickpea, pea, banana, palm and citrus fruit among others), as well as providing application solutions in related sectors.
We support the development of Bachelor, Master and Doctorate Thesis, as well as to provide a solution to various requirements of Bolivian society.
Environmental Microbial Biotechnology
The development of solutions for environmental application is carried out, so we have:
- Bioremediation and Biodegradation of organic and inorganic compounds
- Wastewater treatment
- Biological control of pests
- Renewable energy production
- Biohydrometallurgy Biominery / Microbial treatment of mining effluents
Industrial Microbial Biotechnology
The purpose is the development of solutions for industrial application, so we have:
- Extremophiles and Extremezymes
- Bioconversion and Biotransformation
- Fermentation Technology
- Biopolymers and Biomaterials
- Green Chemistry
- Supports for biomolecules and biofilms
- Food biotechnology
- Antioxidants and food additives
- Polysaccharides obtained from microbial cultures
- Bacteriocins and molecules with probiotic activity
Fungal Microbial Biotechnology
The main objective is the development of solutions for agricultural application, so we have the biocontrollers, identification of phytopathogenic fungi, among others.
MOLECULAR BIOCHEMISTRY AREA
The area of Molecular Biochemistry belongs to the IIFB, where molecular taxonomy studies have been carried out in bacteria, fungi, microalgae, parasites and plants in the framework of the development of different research projects, different pre, post-grade thesis work, publications were carried out national and international and different techniques were optimized: FISH-RNA, PCR-ITS, PCR-RFLP among others. Projects are currently being carried out in the Evaluation of the water quality of tributaries that supply the Achachicala treatment plant, with the chair of Molecular Biology of the FCFB financed with HDI resources, in addition to the Study of the effect of climate change on microbial biodiversity of soils where Chenopodium quinoa Willd crops are grown. financed with resources of the SDC in coordination of the chair of Molecular Biology of the FCFB, UMSS and the cooperation of the Faculty of Agronomy of Viacha, different molecular techniques will be applied, such as gel electrophoresis with gradient denaturation (DGGE), Hybridization in Fluorescent situ (FISH) and amplification of genetic material by PCR to determine the genetic diversity of different microorganisms from different ecological niches and thus be able to apply this methodology according to the needs of the field of Biotechnology.
PHARMACEUTICAL CHEMISTRY AREA
The Institute of Biochemical Drugs Research (IIFB) is made up of four Thematic Areas that work in the Faculty of Pharmaceutical and Biochemical Sciences (FCFyB) of the Universidad Mayor de San Andrés (UMSA). One of these is the Pharmaceutical Chemistry Area (AQF), where research is carried out related to the discovery and development of new alternative treatments for parasitic diseases, based on traditional pharmacopoeias and local biodiversity, using biodirected chemistry as opposed to evidence. Biological in vitro. The AQF is composed of four units with specific tasks.
Natural Products Chemistry Unit (QPN)
Its purpose is to extract, isolate and characterize the active metabolites present in the plants under study.
Biological Evaluation Unit (EB)
Its purpose is to maintain, in vitro, viable and permanent cultures of parasite strains of Leishmania spp, Trypanosoma cruzi, Giardia spp and Plasmodium falciparum, and carry out molecular studies and biological evaluations of all samples produced in the QPN unit and samples of external researchers with whom we maintain collaborative research (CYTED).
Traditional Pharmacopoeia Research Laboratory Unit (LIFT)
Its purpose is to develop pharmaceutical formulations based on plant extracts and / or pure active ingredients, to carry out clinical studies and / or field of efficacy as part of the validation strategies of traditional medicine.
Plant Biotechnology Unit (BV)
Its purpose is to maintain viable, in vitro, viable cultures of cells of plant species and to carry out production studies and biosynthesis of secondary metabolites of traditional pharmacopoeia plants.
Bolivia is included among the mega-diverse countries of the world, and its territory is occupied by diverse ethnic groups that have an intimate knowledge of their natural environment, knowledge that is threatened by the problem of extinction linked to the acculturation of indigenous societies and of the destruction of the environment. Local ethnic groups use plant species in semi-elaborate preparations, with unknown dosages, often, these medicinal plants acquire a magical status and orally transmitted knowledge, from adults, to younger generations, is lost. Since 2000, the Swedish Development Cooperation Agency (ASDI) has been collaborating with the UMSA with an Institutional Strengthening program and the AQF, since 2013 it has been a beneficiary as part of the “UMSA-ASDI Program (2013-2017) Biomolecules of Medicinal and Industrial Interest (antiparasitic) ”. This program allows us to carry out a systematic study of the TACANA Pharmacopoeia, for which we have letters of intentions for collaboration and a calendar of activities, for field and cultural work, with the Indigenous Council of the Tacana Peoples (CIPTA) and the Indigenous Council of Tacana Women (CIMTA). As part of the investigations of the AQF-IIFB, between 2007-12, clinical studies have been carried out in the validation of the use of the species Evanta (Galipea longiflora) in the treatment of leishmaniasis and intestinal parasitosis in school-age children. Currently, we are still looking for new antiparasitic agents among the plants used by the Tacana ethnic group, based in the Bolivian Amazon.
Biological Evaluation Unit
Natural Products Chemistry Unit
It has the units of:
Toxicity - Genotoxicity
Natural product development and quality control
Lines of investigation:
Research in DIABETES, are linked to conducting scientific studies of plants and / or foods as a source of new therapies for type 2 diabetes, which involve preclinical studies in animal and cell models, and concomitantly clinical studies. The development of the research is carried out in a multidisciplinary way and jointly with the Karolinska Institute - Sweden and Laboratorios Agronat SA, there is funding from the Swedish cooperation ASDI (2013-20127), and IDH resources (2015-2016).